While I agree with this, it's definitely not the position I see here often. The quick flip or at least buyout-as-a-business-plan seems far more popular and glorified.
I guess I can understand that, to a point, but it indicates a very naive view of success and an unrealistic idea of what business is actually like. Unfortunately, that's echoed and reinforced in many places -- intentionally and otherwise -- YC and its surroundings being among them.
I like the premise here. I think it's simply that motivation comes from the belief, valid or not, that you're really doing something that has serious potential. He doesn't quantify what that means, and I think that's best... "big" means whatever it means to you, whatever motivates you, because that's what will make you feel like you're doing something important.
I'm not a feelings person when it comes to business. But being a solo founder, those ephemeral little buggers are important.