Confusing "the odds of this occurring with a fair coin" with "the odds that the coin is fair" is by far the most frequent statistical error I see, and by far the least often corrected. It's mildly terrifying.
P(H0|observation) = P(observation|H0) * P(H0) / P(observation)
P(observation) = P(observation|H0) * P(H0) + P(observation|!H0) * P(!H0)
A normal significance test tells you P(observation|H0). [Though I'm not sure about P(observation|!H0)]. To apply Bayes' Rule you need P(H0), where P(H0)=???