You plant the seed for the violent revolt of rampaging gamers that will ultimately see Disney surrender the Monkey Island IP to restore global peace.
Then you make a game.
Then you make a game.
I think that any new game with same quality, the humor and mechanics, but in a different setting (or heck, just a different name!) would still be loved.
See for example the success of every new Civ game compared to the success of other strategy games.