It all comes down to the fact that the Unity launcher is forcibly placed on the right hand side and I always accidentally click on it when trying to click somewhere in the region. No other OS I use forces such a thing, which is why I will never get used to it.
I tried changing my mouse sensitivity to compensate for the bar, but it makes everything else harder. There used to be a hack that would let you move the bar to the bottom of the screen, but it has not worked in the 12.x versions.
I use KDE these days. The worse thing they force their users to look at is the Cashew, which can be made transparent by installing a third party widget.