Not any more uncomfortable than single tapping any other part of the screen one-handed. Of course this depends on screen size...
what if you wanted to zoom in to a position near the top of the screen?
Point well taken.
Assuming that the content of interest is a good centimeter or so in from the edge, you could map that point-to-edge distance to cover the remaining zoom scale. If it's inside that centimeter, zooming into the middle is useless anyway.