To be honest, I never used one. It came installed on my stack and all I did was disable apache, enabled NGINX and PHP-FPM (cgi compiled php, quite a bit faster).
Look at php-fpm (FastCGI process manager) which has been bundled with PHP 5.3+. On the nginx side, you would configure it to use fastcgi_pass. An example configuration is available in the Silex documentation: