How are you applying? Maybe this goes without saying, but it's not nearly enough to go on a VCs website and fill out a form. Having managed dealflow for a while at a VC before, I can tell you that they will often mostly ignore the applications from their webform because there's so much noise/junk from it.

Find a way to get an intro. Talk with people at their portfolio companies. Meet with non-VCs in your space that likely have VC connections, make them advisors in some capacity, and ask them who they can introduce you to. Send them something exciting, that they'll talk about. You have to find a way to make yourself a qualified lead, or at least interesting.

If you're getting the meetings, but no interest, that's a different issue.