Let's take Clojure for example. That's a high level language by anyone's standards, and the code can be made easy to reason about. However, due to being built on top of the JVM means that when dealing with bugs a knowledge of the JVM (and Java if you're using Java libraries) is beneficial. Now that the high level view doesn't tell you the full picture, you're making the search for the bug quite a bit more involved, as not only do you need to understand the bug at the level which its occurring, you need to fix it at a level abstracted away from the one where the bug can be seen.
But by and large, yes, high level languages tend to be easier to debug due to smaller code bases.