It's decent, but I switched to Qt when the licensing changed and definitely do not regret it. YMMV, but I find it the most pleasant and complete GUI toolkit of any language. wxWidgets makes you do more stuff manually. For example, I've found sending custom events to be a fairly complex and error-prone process, requiring badly-documented macros, while Qt makes it a breeze with the signals/slots mechanism. Qt also offers much better integration with VS, eclipse, etc. wxWidgets does have a fairly usable stand-alone designer.
I don't know about dabo, but having used both toolkits, and now that Qt is LGPL, I don't see any serious reason for choosing wxWidgets over Qt. Personally I use it from C++, but if you want Python I'd suggest having a look at http://wiki.python.org/moin/PyQt .