* I wish my body didn't start to break down as I get older.
* Related to that there are a whole host of diseases and disorders that I'll probably get one of and die from one day.
* I wish I didn't have to spend so much money on energy (not just directly on my monthly bill, but as part of the cost of almost everything I buy).
* I wish my internet connection was 100x faster.
* I wish I could travel to California from NY without having it sit on a cramped airplane for 5-6 hours.
* I wish I had a thinking interface to computers instead of having to take my damn phone out of my pocket and peck at it to get it to work.
* I wish my memory could be augmented in some way. I'm forgetting things all the time and that's really annoying.
* I wish that learning new stuff wasn't so hard. Can someone build on of those machines they have in the matrix so I can just download up some knowledge. I want to know Kung Fu!
* I worry about global warming. If everyone was as rich as Americans and lived like we do it seems like we'd have some pretty big problems. Can we do something about that?
* I hate that when I order something from Amazon I have to wait so long for it to show up. Why can't a machine in my apartment just zap it into being instantly? They've got that in Star Trek and it looks pretty awesome.
* Speaking of Star Trek, I'm bored of living on Earth. I want to go to the moon, or mars, or another solar system! How could we possibly do that?
OK. That's just five minutes of random thinking. I'm sure that I (or you!) could come up with many many other Big Problems.