This must be wrong. Surely if Destructoid are seeing a 50% block rate, their competitors must be seeing something similar too? A world with ad-blockers is the new normal for everyone.
Ad-blockers aren't going away. The fundamental architecture of the internet and the web makes it almost impossible to force people to view ads that they don't want to, and no advertiser is going to win the technological arms-race against the ad-blocking software. For now, at least, I have sufficient control over my own computer that I can dictate what appears on the screen.
I think the right conclusions are reached in this article though. Destructoid clearly understand the marketplace they're operating in, and a membership option of some kind is a good, non-exploitative way of earning money from content creation. It might not work, and there might be better alternatives, but someone is going to find a way that does work. The existence of ad blockers is providing "evolutionary" pressure toward business models that don't rely on spamming people with crap, and this is a good thing. (Assuming, that is, that the new business models aren't somehow worse, at which point we'll have to start blocking those...)