Two problems with the HTML5 version in Chrome:
1) No audio
2) If my mouse cursor moves off the window it loses control of the ship
Flash version has neither of these problems.
No idea why audio is broken. I tried a couple HTML5 audio test pages and it works there.
I'm using Chrome beta 26.0.1410.28 on both Windows 7 and OSX Lion, broken on both.
I didn't notice any other differences.