If we just mean to break them up into smaller banks, it is hard to say whether negating the benefits of scale will raise costs higher than the competitive pressure of no longer having dominant institutions effectively being able to set prices.
If we mean to break up securities trading and deposit-taking divisions into separate institutions (as Glass-Stegall was meant to enforce until repealed) then we may see a return to a more stable Wall Street, as the house would be forced to play it's own money instead of yours, and 'banking' will be pure and boring again.
The implicit and even explicit backing of a government of a private institution, forced as a result of that bank's size and market impact, allows that institution to take larger risks and to privatise profits that are generated as a result of the public's support.
This is a major unintended consequence of saving big banks during the financial crisis.
http://www.theatlanticwire.com/business/2013/02/banker-bonus...
1. Banks don't have to value their assets at market price (that whole mark to market issue)
and
2. Banks are currently trading below their book value, because, from what I've read, nobody really trusts the value of those assets.
So, it could in theory spark a new global panic by people shorting banks and withdrawing capital.
http://en.wikipedia.org/wiki/Breakup_of_AT%26T
You Canadians have it figured out, your banking system seems far more efficient with larger regional institutions.
Another one would be: target of acquisition of a bigger international banks (HSBC comes to mind). Slowly the govt. has to regulate that as well or else ...