One of the things they explicitly call out is DNS late binding: it doesn't look like they make any exceptions for CDNs and other services that use geo-IP lookups. You could argue that the speed improvements do away with some of the need for CDNs, but there will probably be some other cases that this breaks. You'd want some way for a specific domain to opt-out: perhaps a DNS text record that gets read and indicates that a site shouldn't be optimized?