When I saw zopfli, my immediate reaction was that it should save a non-trivial amount of money for us while leading to a slightly faster download for our users. Hearing a 100 times increase in compression time doesn't sound like much compared to the number of times the files are downloaded right?
The last incremental patch we did to the game took 79 seconds in our build system to compress with the usual gzip. This is only compressing the files that were changed since the last patch, not the entire game client, so larger patches would take longer. If we changed to zopfli, it would take 2.2 hours.
That would put a serious dent in our agility. When we are trying to deploy a new patch, adding 2.2 hours (or more) somewhere in the middle of it really isn't viable. (It's already maddening when the rest of the process takes ~40 minutes with all the automated tests that we run).
So then lets look at the savings that this would buy us. We distributed about 30TB yesterday. Bandwidth costs 2c per gig. This would save us about 30 dollars a day.
So much for that!