Is there some hack around the East Texas problem? If you don't sell your product in that area, would it be possible to avoid being brought to that district's court? If so, I could imagine companies could simply have a notice on their checkout page: "Sorry, you live in East Texas, we don't sell there". I'm sure some companies would not want to leave money on the table like that, but for many things I do, I'd be happy to take such a position.
If blocking IPs that originate from that region would offer additional protection from patent trolls, I'd do it in a heart beat. I know that the real answer is "talk to a lawyer" which I will do, but it'd be interesting to see someone from the Hacker News community comment on the viability of this strategy.
Maybe we just need a bunch of people to move there for a few years and upset the status quo?