For transporting big things: it's more efficient to have larger rotors than to have multiple rotors.
For transporting really big things: see above, and helicopters have been around for a long long time; "we" (not me) have decades of experience with helicopters; you probably really want something that is safe and reliable. You can't just scale up your model.
As for quadrocopter piloting: right now, all pilots crash. Repeatedly. Luckily, repairs are cheap (unless you happen to carry an expensive camera). For a full-size aircraft, crashing is probably not an option, so add lots of dev/testing time for safety features and pilot training.
BTW (somewhat unrelated): One huge problem with (smaller) quadrocopters is the many people that start new copter projects and get nowhere instead of contributing to one of the existing major projects or reusing its soft/hardware. Some of these projects are already way beyond what a single person or even a small team can achieve in a few years work.