I've only been on one job interview where the hiring manager looked at my github account prior to the interview
Oftentimes, the great coders are so anal about the code they write, that it's highly refined, well organized and thorough (mostly because they can't attach their name to bad code, especially when it's public). Those are the guys you really want on your team.
Of course, I've gotten ones with a github url with no repos in it or some piddly little thing, and that sends a different signal.