It depends on what you need, but I'd say yes, as long as they natively support whatever language and database you're using. I usually use Lighttpd for specific (non-general) projects requiring lighter implementations. Actually, I think that the more specific your requirement is you may switch to more tailored solutions. One examples are WAF's like Rails or Play!, they use non-LAMP components like SQLite, Ruby or Java in addition to using their own webservers.