Its futile to argue with them that vaccines aren't (statistically) harmful, they've already made up their minds. So I agree. All medical interventions are harmful in some cases. Instead, I simply ask them what makes them special that they should be allowed to avoid the small risk of the vaccine as opposed to everyone else. After all, if no one was vaccinated, there would be polio epidemics, which most will concede are worse than the risks posed by vaccines.
Asking them why they are exempt from preventing polio while everyone else must shoulder the burden often turns a mindless stream of conspiracy jargon into an almost stunned pause.
I'd pay for an app that runs this simulation just to make this point sharper.