It's a (almost confusingly) controversial topic, but there is a lot of good that could come out decriminalization. I've never done any drugs myself, but I can think of a number of business opportunities not only in legal narcotics trade, but also supporting industries. If the objective, empirical evidence suggests that it does not present society with an immediate nor a long-term health threat, then the economic and cultural benefits would be exciting.
That said, it will be a considerably long time before metaphors like "The war on drugs" are dropped in the US. People are passionate about it here.