I went to grad school with a guy who, while traveling in Brazil, encountered a shaman/teacher, and decided to take a so-called "heroic dose".

Apparently the roof of the sky ripped open and voila, GOD. Was a bit much as he took 2 years to recover and, AFAIK, has been substance free ever since.

Also know a guy who lived in the Amazon taking Ayahuasca daily for 6 months -- came back stateside completely & utterly beaming with joy.

it seems, YMMV ;-)

p.s. why do threads on the use of psychedelics pop up on Hacker News? Thought this was for start ups and general technology topics...