In that video the quotes to which I guess you are referring are "[investing] is almost entirely a non-professional role" (08:40), "[Market-making] is a highly professionalized role" (09:13), and "[an arbitrageur is a] highly professional role" (11:22).

I thought the video had something in support of your "price prediction is the hard way to algorithmic profit" statement, but I can't find anything very explicitly in support of that (what I thought was your implication). He kind of implies something like that at 15:00 when he says "we have no idea how [price prediction] works [at longer then a few days in the future", but that's not really very strong.

When you said "active trading on signals [...] is the hard way", did you mean active trading at minute-to-day or greater holding periods? That seems a) right :); but b) slightly at odds with your "it's important to have level II data", since I would have thought that is less important at a hourly-to-day or greater holding period.