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Form factors, no. Screen sizes is reasonable.

p.s. didn't notice this until just now because it wasn't a reply to my comment and so didn't show up on http://news.ycombinator.com/threads?id=quarterto

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My bad on the reply (or lack thereof). I agree to date responsive gives a generally better experience for most sites. I don't think however it's the best solution for mobile design.

It compromises usability through a changing of the interface, there is no reduced markup size and it's a very costly endeavour.

Bad responsive design compromises usability - good responsive design applies itself to the context and enhances usability.

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