Let's see.
To the businesses, MS has nothing substantially new or exciting to offer.
True, desktop usage will probably remain about the same (with a slight decline), but meanwhile, the mobile computing world is growing rapidly, with MS being largely out of the picture.
Desktop OSes will continue to sale, but they become day-by-day a very small fragment of the OSes out there.
Win7 is a great OS, but I'm sure various alternatives, coming from the mobile world and leveraging their success there, will try to replace it.
I love Windows (7), use Visual Studio and other Microsoft tools daily, but this has nothing to do with the real changes that occur in the tech world.
MS bet wrong, and as occurs in the free market, they'll lose.