"I was told confidentially by an IT Security specialist from a major bank that the public would be shocked if they knew the amounts that are stolen daily from online financial institutions via ACH and wire fraud. Typically, breaches and total numbers are not revealed because they don’t want to advertise a weakness and they certainly don’t want to alarm customers. Some of the more vicious attacks are State sponsored. I believe him. That’s what bitcoin is up against as it progresses into the mainstream. The leading security experts are in that world, already protecting against the barbarians at the gate. They are not in the bitcoin world."
That said, I don't think it's an impossible task (is anything?), and I'm sure some day there will be a large disclosure through some means, internally-assisted or otherwise.
Modifying or updating anything on the server required physical access.
That server was located in a secure vault.