There are several programs that build on the Metasploit Framework and take advantage of it. Rapid7 has commercial penetration testing products. I build the open source Armitage GUI for it and a commercial add-on called Cobalt Strike.
It's worth spending some time to learn how it works and what it does. Here's a few links:
Metasploit Unleashed Wiki: http://www.offensive-security.com/metasploit-unleashed/Main_...
My 7-part course on pen testing (with Cobalt Strike & MSF): http://www.advancedpentest.com/training
Quick demo of what it looks like to attack a workstation and use it as a hop point to get other things: http://www.youtube.com/watch?feature=player_embedded&v=S...
The best way to try the Metasploit Framework is to setup BackTrack Linux in a virtual machine: http://www.backtrack-linux.org/
A free vulnerable target is the Metasploitable virtual machine, available at: http://sourceforge.net/projects/metasploitable/files/Metaspl...