I am applying this methodology to Knuth's TAOCP. So far so good, as I am actually getting through the book this time, because I am just doing the initial read through. TAOCP always used to stump me when I've tried to go through it before because I normally try to understand everything I read before continuing a book. This way at least I am building up an understanding of what I need to learn to be able to understand the book.
One of the key features of Adler's methods, which he emphasizes in _A Guidebook to Learning_, is to "read and discuss". Those who have access to discussion with other learners or mentors, whether in a work or school environment, I think have a great advantage compared to those learning alone.
So I actually need to read that book twice ?
I'm only half-joking here... It's a semi-serious question!
In developing the skills of reading, initially one may need to read stuff twice. With skill and practice, one reading may accomplish several kinds of goals at once.