This is, in my opinion, the single largest problem with tile matrices that have unrestricted length and width. Its very hard to tailor the reading experience to be anything better than mediocre -- and at times on short, wide screens, its downright awful. Windows 8 makes a mess of things by scrolling sideways in landscape mode, then up and down in portrait mode. Readability is sacrificed at the alter of adaptable design. The tiles lead the eyes no where -- because content can really go in any direction (up down left right? why not down through 3D or even up or spinning maybe too? They are all done in Windows 8)
The other thing tiles do poorly is constrain the variances on line lengths by boxing them in. When you scan headlines, you naturally grip the page using the various headline lengths. Boxing them in and cutting them off makes every headline appear the same length and kills their distinguishability (and implied reading direction).
Ultimately, I believe its most comfortable read across the most narrow dimension of a screen -- depending on orientation -- then scroll the opposite of the reading direction.
That being said, users will also tend towards their native reading direction (Japanese users will read down, English, readers across from left to right, Arabic from the right to left)
Discloser: Im a UX and UI designer who has worked on Windows 8, iOS, Android, and about 10 other operation systems. I have also designed mixed language or language-free interfaces to varying success.