Yeah, I'm sure they're out there, but it's very rare in my experience. I'm a micro-brain when it comes to cracking software, and I've almost never encountered this, whether it's small fry software or something from Microsoft or Autodesk. There was some software with debugger detection I came across once (can't remember which it was), but that's the kind of thing where lots of existing workarounds often exist by other crack-ers.