And reducing exposure to US sanctions (for example by investing into alternatives to Windows or Visa/MasterCard) is an appropriate response for the affected countries.
You can complain about well America is sanctioning countries I disagree with, but it also affects countries you would agree with. When we don't have sanctions power perhaps military force gets used more.
Regardless of what happens both the EU and America are still within each other's spheres. That's not going to change anytime soon. We've gone through much worse.