What are you talking about. The phenomena are adequately explained. I can measure a Kd and make mathematically modeled predictions that will come true. I can even phenomenologically test contributions to the Kd (ablate hydrogen bond, delete or add a charge, etc)

Nature is under no obligation to make explanations trivial to a human brain conditioned on quotidian macroscopic observation. Doesn't mean you have to appeal to quantum woo. We know more or less how much "quantum mechanics" (for some definition of QM, obviously an electron shell is QM, but for all intents and purposes you can just treat it as a classical ball that does a few weird things like bonding) contributes, to, say reaction rates. It's nonzero. It's nearly zero, though.