Esoteric languages like BrainFuck are esoteric and difficult precisely because they go out of their way to eschew conceptual links to existing languages or paradigms.
So if you invented a new type of esoteric language with arbitrary syntax and strange operators (not sure how you’d do that, exactly, iirc all fundamental binary operators are known) it might be impossible to use with an LLM even if the user manual was in context… but aside from that, languages and the underlying concepts are extremely generalizable.