Databases are much more tricky, but if we're talking a significant shift, it is as good a plan as any. Clearly server trust is not working.
AI is accelerating both sides for defenders and attackers, but mobile clients are already way ahead of typical desktop. Android's desktop mode exists in the OS now but needs a lot of work and more powerful chips before it can replace desktops.
For security against remote attacks, I'd rank clients roughly: GrapheneOS, iOS/iPadOS, stock Android on Pixels, ChromeOS, macOS, Windows, desktop Linux. Prefer more secure clients, always, but now the client is all that's left to trust for content.
Native clients avoid the web E2EE problem and are easier than ever to build. With AI, you can audit the source as often as you want and reproducible builds mean you know that's what you're running.