Yeah, please have knobs. I don't mind a bit of screen, but all the frequent stuff I want in knobs.
Provided there's steering wheel and stalk controls, what do I really need to adjust on a center console while driving? I just want a big nav map or camera feed there.
The only notable thing I couldn't do was adjust the fan level if it was on automatic, but I could turn it off.
IMO if you might need it while driving it should be on the wheel or the stalks. Center console? That's for my passenger to mess with only, or for when I'm stopped.