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Comment by m-chrzan | Hacker News Reader

>Speaking from personal experience, vaping is far more addicting.

Sure, and I'm not disagreeing with that. I disagree that "degree of addictiveness" is the metric that's wise to use when choosing a nicotine delivery method. Obviously the #1 choice should be NULL, not smoking at all, but if one is already addicted to nicotine and not ready to quit it at the moment, smoking cigarettes is, as far as we know, the worst option. Even intermittent smoking, or low-volume (like your 3-4 a day) causes non-linear harm. See this paper for example: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.9... .

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Do we have the numbers yet on the effects of vaping all day every day on cardiovascular health and lung cancer?

Also nicotine itself is not without harm. I always thought these drugs only affect the brain, but they're metabolized by the whole body and have consequences on all your cells https://pmc.ncbi.nlm.nih.gov/articles/PMC4363846/ Trading the terrible effects of burning tobacco versus the insane amount of nicotine from vaping seems like an unknown tradeoff to me

>Do we have the numbers yet on the effects of vaping all day every day on cardiovascular health and lung cancer?

Not that I know of, and I grant that this is an unknown, and we could end up learning about extremely bad 20-/30-/40-year effects in the future. That said, there are very clear, very significant, and very well studied harms of cigarette smoking. Research is being done on vaping, and so far all harms identified are significantly lower than smoking.

>Also nicotine itself is not without harm.

Sure, and thanks for the paper. I'm not well versed in bio enough to tell the significance of everything in there, but, correct me if I'm wrong, for the most part this is showing there exist harms, but they're not particularly well quantified yet, especially in terms of human subjects? For this to really matter, you'd need to quantify the surplus of nicotine you get from vaping vs. smoking, and then compare the relative harms of those two doses. Could be that 5x the dose causes 5x the harm, or could be that the smoking dose passes some threshold, and 5x the dose from vaping is just marginal additional harm on top of that. And then still compare that to the other differences between smoking and vaping in terms of harm.

Keep in mind 5x the dose is relative to being a pack a day smoker. We're talking 20x if it means smoking 4-5x a day.

Then there is the negative effects of I dunno how many multiples of volume of vape in your throat and lungs, which I assume is non-zero even though I personally believe its 100x better than burning tobacco.

Then there is the question of what that much nicotine does to you mentally, which is equally, if not more important. To put it in perspective, I usually wake up feeling pretty good, with some hopes and dreams of what Ill be doing that day, and Ill take a puff and immediately want to go back to bed for another hour. I cant sit in meetings for more than 5 mins or have conversations with people if it means I cant be vaping. Its like basing your whole life based on whether you get your fix of nicotine or not. Work from office? I don't think so buddy...every ten minutes Id have to go to the bathroom/outside. I seriously wonder where my life would have been if I never picked up this habit.

We'll see in another 10-20 years I suppose.

> Do we have the numbers yet on the effects of vaping all day every day on cardiovascular health and lung cancer?

Even when we don't have the numbers for everyday long-term use we already know the chemical and biological mechanisms that make smoking so harmful and carcinogen and we can measure that these substances are almost entirely absent in vapor during normal use of a vape because almost all of the problems with smoking come from burning tabacco and inhaling the fumes and vaping is simply way cooler and there is no fume but vapor (hence the name) and we know that the potential of vapor to do harm is way lower than fume. We never have any long-term data for anything new. But to make an argument for not consuming something you would at least have some reasonable mechanism through which it could be harmful and a lot of those known to be harmful mechanisms are present when smoking but absent when vaping. Even the British National Health Service agrees that vaping is at least 95% less harmful than smoking and this is a reasonable position.

> Trading the terrible effects of burning tobacco versus the insane amount of nicotine from vaping seems like an unknown tradeoff to me

This is just black rhetoric that is not evidence-based. How do you know the amount of nicotine is "insane" during normal use?

All available evidence points to vaping being at least one magnitude less harmful than smoking and this is backed by what we know about chemical and biological processes of the chemicals involved and through medical reports about people who replaced smoking with vaping. It would be irresponsible to deny smokers who can't quit a way to harm reduction just by claiming we don't have any long-term data. We know enough about combustion, vapor and the chemical and biological implications to be quite confident that vaping is much less harmful than smoking.

That doesn't mean we should promote it to anybody who is not already a smoker. But as a means to reduce harm for someone who seems unable to quit smoking it should be considered.

I think you read my comments as some self assured statement or argument whereas I was genuinely asking questions.

I dont doubt given an equal amount of vaping to equal amount of smoking, vaping is far healthier. But to what end? Is smoking 1 cigarette a day worse than vaping 2-3ml of 50mg/ml nicotine? How about 3-4?

As far as I know the academic consensus is that taking in more nicotine, even a lot more, doesn't turn vaping into something as harmful as smoking. Addiction is the main established "harm". Nicotine, even very much of it, is not considered a carcinogen. There are studies that suggest it could promote tumour growth but it hasn't been shown in humans. There is also decades of data from nicotine replacement therapy and Swedish snus users and it shows little to no increase in heart attacks or strokes in otherwise healthy people. Another risk is accute poisoning, i.e. swallowing large quantities of liquid by children. As far as I know even the more alarming voices regarding nicotine do not regard it as harmful as inhaling fumes from combustion.

Also I don't think that there are many people that overdose nicotine regularily because it causes nausea and dizziness so people are normally self-regulating the nicotine dose automatically. So the scenario you are proposing doesn't seem to be something we can actually observe as a common consumption pattern.

Too much nicotine is far closer to drinking too much coffee than to smoking and has similar acute effects which is why almost nobody does it on a regular basis.

Vaping definitely isnt healthy for you.

It's not really the nicotine that causes the obvious damage though. Studies have shown that the vape smoke stimulates the vagus nerve which causes changes in the cardiovascular system that could likely cause heart disease

On top of that it’s obvious that what goes into the lungs generally stays in the lungs, and vapes are full of all sorts of weird flavours and e numbers

But the truth is even if you were vaping water all day it would likely still damage your cardiovascular system

> Vaping definitely isnt healthy for you

nobody claimed otherwise

> Studies have shown that the vape smoke stimulates the vagus nerve which causes changes in the cardiovascular system that could likely cause heart disease

Can you name this study? Are you talking about "E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice"? This study did not find what you claim. All it found is that in mice the heart rhythm during and right after exposure increased. This is far from claiming that it "could likely cause heart disease" in humans. Also human switching studies point the other way. smokers who move to vaping show improvements in blood vessel function within weeks. I don't know why people really need to twist study results to depict vaping more harmful than it is. Yes, it is not healthy and you shouldn't do it. But all scientific evidence conclusively points to vaping, even heavy vaping, still being way less harmful than smoking because we already know that basically all harm comes from inhaling the residues of combustion, not from the nicotine. Condeming vaping as being equally bad as smoking is irresponsible and unscientific and prevents proven harm reduction for heavy smokers.

> Condeming vaping as being equally bad as smoking is irresponsible and unscientific and prevents proven harm reduction for heavy smokers.

I never said this did I.

Also you’re talking about smokers moving to vaping, whereas at the moment plenty of people are going straight to vaping due to people over arguing how harmless it is compared to smoking.

Addiction is a disease, not a "choice"

And "not ready to quit it at the moment" is such a wildly inappropriate dichotomy I really wonder what experience you have which informs your decision to discuss this topic.

Also I want to mention, I feel like there is too much emphasis put on length of life and not enough on quality of life.

If smoking 3-4 a day is far worse on my body BUT it means Im not a nicotine fiend with a brain fog all day every day with zero motivation, Ill take it.

But smoking cigarettes shortens life. Why would you want to promote vaping as improvement on the quality of life? Also, why do you write nicotine fiend - you are aware that tobacco plants contain nicotine? Vaping may be less damaging than smoking. I fail to see how it is healthy anywhere at all. Why do people here on this sub promote either thing as an exclusive or? That makes no sense. People need to stop sugar-coating crap. I also noticed this with weed. Weed users always say how weed is no problem, but it ALSO is a problem. Their brain tricks them into becoming a promo-individual for weed suddenly. Weed changes the brain pattern too.

I think you misread. I am saying vaping 5x the amount of nicotine is far worse mentally. Even if smoking 3-4 a day is worse physically, if I am going to do one or the other, I rather smoke 3-4 a day.

But in general I am saying, even for the quitting smoking/vaping ad campaigns there is not enough emphasis put on how dramatically it reduces your quality of life. Its always about dying of cancer or heart disease and living shorter amount of time 20-40 years down the line. I mean shit in a lot of cases I rather die at 70 than live to 80. Youll feel better EVERY day in a month is a muucch stronger motivation for me.

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