We used to run it on our Grid nodes, and while it was not bad, it was not that smooth, either. It was a little kludgy but worked if you didn't diverge from the happy paths much.
Now Debian has Extended Long Time Support via Freexian, I believe CERN has enough confidence to use Debian instead of RH family, and that will make lives of some people way easier. Debian is still easier to manage than RH based systems, and .deb is a really good package manager, and is arguably more sophisticated than RPM.