The underlying program was in trouble. NASA had already concluded before Isaacman took over that the existing Mars Sample Return architecture had become a roughly $8–11 billion project with samples potentially not reaching Earth until around 2040.
So yes: NASA killed the bloated $11B / 2040 version of Mars Sample Return.
Isaacman is pushing NASA’s Mars program toward cheaper, faster, modular missions, greater use of commercial spacecraft and launch providers, and infrastructure that can support both science and eventual human exploration.
That makes the “NASA is abandoning Mars science” framing fake news. NASA is abandoning a specific, extremely expensive architecture.
Isaacman has explicitly left open the possibility of retrieving Perseverance’s samples through a different approach.
The real question is to what extent the new model will actually deliver the samples faster and for dramatically less money.