I used btrfs raid0 on USB drives for more than a year. Every month or so, a drive would disconnect from the bus and immediately redetected as another device (sde->sdf). Btrfs does not auto-recover from this. The choices are 1) reboot and scrub, which recovers the missing drive without doing a full resync, but it needs a reboot (any hosted site is offline for 3 minutes) and scrub takes a long time reading in the background, or 2) run btrfs replace which doesn't need a reboot, but the full resync takes even longer than a scrub and increases wear if it's a ssd because it wipes everything and writes all data again.