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Not to mention "www", which when pronounced is actually three times longer than its expansion.

You could shorten it to “sextuple u”.

Great minds think alike, but my concern was that sextuple-u sounds like you're about to tackle someone and do something.

Plus it's still cumbersome to say. But I guess "sex-u" is right out.

For a native speaker in casual speech, it'll only be at most a bit slower than its expansion because English is stress-timed