The slowness of Python based software, and the continuous rewrite of Python into C, C++, and nowadays Rust.
I know of very few cases of this. For the most part I find the "slow" to be in the network/IO things. Unless one is doing heavy matrix math or something similar in pure Python, which I'd seriously question.
It's essentially the same re regular desktop software. The performance for a particular bit may be nice, but it really doesn't impact the overall experience as one can only move at a certain speed as a user, and there are still those other bottlenecks. Like with my current project that's using Flet, the UI is extremely snappy and a joy in every way, but the networking bit (using iroh, which is implemented in Rust) has been a constant pain that I have to keep returning to. The speed of Rust is doing 0 to help anything, and I feel like it would've been less painful if iroh was actually implemented in Python as then I could dig into the source to see what's up and tweak to fit my circumstances, instead of dealing with essentially an immutable black box.