I don't think so. So far all fatalities [0] happened either during launch or during launch or during landing. The only fatal incident that happened technically still in space (above the Kármán line) is Soyuz 11 [1], but it happened after the landing sequence was already started, so the capsule landed normally, just with the dead crew.

It appears that just hanging out in the orbit is relatively safe, going up there and going down is risky.

Same with aircraft, btw, most accidents happen during take-off, shortly after take-off or during landing. Cruising at a stable altitude is very safe.

[0] https://en.wikipedia.org/wiki/List_of_spaceflight-related_ac...

[1] https://en.wikipedia.org/wiki/Soyuz_11#Re-entry_and_death