I researched a bit on how to manufacture PCBs at home, and i came across Voltera V one. The price is indeed way too high, but I am hoping somebody will make a foss version of it. There are already pretty interesting foss PnP machines.
For a 2-layer pcb I would either go chemical etching or a small routing cnc. Chemical etching kits , uv lamps and blank pcbs are not "too" expensive, but it's more of a professional setup than a hobbyist. Just think of all the PCBs yoi can send to manufacture (and with 4 layers and more) for the price of even getting half the stuff.
real PCBs are so much better than anything you can do at home, and so cheap, and so easy to order now, it's just not worth it
For a small lab where you have a moderate volume of oneoffs it's worth the investment. But, yeah, I wouldn't have that setup at home.
At current PCB prices that's kinda not worth it. Hell, even actual assembly isn't that expensive (at least if you have "a lot of few components" vs "big variety of components").