Psychology explains why you feel tired by pointing to biology. Biology explains why cells need ATP by pointing to chemistry. Chemistry explains why ATP releases energy by pointing to physics. Physics explains that by pointing to some higher level form of physics like thermodynamics, which points to statistical mechanics, which point to quantum laws. When you get down to a certain level you simply have nothing left to punt to. You simply accept it because it's what's observed and makes reproducible predictions or you don't and go study philosophy or religion or something.