Home computer games being written in compiled languages was never a blocker to mod them, if anything maybe more folks should improve their Assembly programming skills, and discover how the Demoscene was born.
It's doable, but more difficult. Also, digital distribution platforms will overwrite your modified binaries with abandon, considering them to be corrupt. Of course, if mods are supported anyway, they could be supported through dynamic loading, but that's still inferior to the power afforded by e.g. Harmony and a good JIT compiler.