Entirely new works are often created entirely from samples, and can be amazing. See "Frontier Psychiatrist" by The Avalanches for one example done entirely by humans. There are many others.
We reached that point with humans long ago. There's nothing new under the sun. Only remixes of dead peoples greatest hits. The pentatonic scale, for example, was not invented by the people who use it.
Science and art would have to start over from scratch if you expect things to all be genuinely new from first principles.
> who will make it if it means it's going to be consumed by data centers immediately
People who enjoy making it.
The demand for paintings did not disappear when photography was invented. Though many Luddites claimed it would. There were even those who wanted cameras outlawed to protect the artists livelihoods. Do you think we should have listened to those people?
Is this situation different from that one?