Of course I am biased because I work in the field, but the by far most wide reaching application of Cherenkov radiation is in the detection of high energy particles, particularly in astrophysics.
- Imaging Atmospheric Cherenkov telescopes detect the Cherenkov radiation emmited in the atmosphere when a high energy cosmic ray or gamma ray creates an air shower
- Water Cherenkov Detectors detect Cherenkov light when the secondary particles of these air showers reach water tanks on the ground
- Neutrino telescopes like kamiokande, Icecube and km3net detect Cherenkov radiation in water or ice produced by secondary particles produced by the rare interactions of Neutrinos in their detector volumes
Modern, high energy astrophysics is all about detecting different kinds of Cherenkov radiation and then reconstructing the original particle properties.