Someone once told me that success and fame don't change a person. They merely amplify that person's qualities; you're still the same person.
Also. One of the advantages of Silicon Valley being an insular bubble at times is that however successful you might be, there's someone within a few square miles who has accomplished more. It's easy to get constantly humbled.
For every Drew Houston there's a Mark Pincus and for every Mark Pincus there's a Bill Campbell.
Obviously take everything I say here as just my own personal experience and my company is very very very early. But these are just some personal notes & thoughts.