> The world ships more than a billion capable phones, tablets, and laptops a year, most with a chip built for exactly this work, paid for and idle most of the day. Run the model there and the economics flip: no per-call cost, no round-trip, and nothing leaves the device.

This. I run small models (>50MB) for bio-imaging/biotech applications, it feels like every README implies that you need a discrete GPU to get started. While some do, many, especially the most useful ones, do not. Sure it matters if you're also going to do fine-tuning, but I believe your typical user just wants to detect some nuclei and get some cell-body ratios.

The laptop on your desk won't be running Meta's SAM, but it has more than enough compute to crunch 100's of your H&E slides overnight.