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But what would be the business model for such a desktop app?

Selling licenses, like most commercial desktop applications.

Very long sales processes but yes. It is better to be a Salesforce-like platform... How Salesforce did to enforce a cloud platform as a SPOF for CRM?

Eh, how so? Put in your credit card details, and the download starts.

sorry but no download with Salesforce, (following my request) and they are still SPOF for CRM right?

But yes for a desktop you are right. "credit card details and download"